Autofagia en el Contexto del Sistema Estomatognático en Enfermedades No Neoplásicas. Revisión Sistemática Exploratoria

La autofagia es un proceso de degradación lisosomal y protección celular, que está destinado a eliminar los orgánulos dañados, las proteínas mal plegadas y los patógenos intracelulares, por lo cual es un importante proceso para la salud en los humanos. La autofagia actúa como modulador de la patogénesis y es un objetivo terapéutico potencial en diversas enfermedades, como el cáncer, la diabetes o el Parkinson. En relación al sistema estomatognático, la autofagia actúa agravando o protegiendo las enfermedades orales cuando se encuentra aumentada, activada o alterada. La desregulación de los mecanismos de la autofagia repercute en el desarrollo de la autoinmunidad a través de la supervivencia de linfocitos T, participa en la disminución y degeneración de células glandulares y queratinocitos basales en patologías como el síndrome de Sjögren o el liquen plano oral; participa modulando la inflamación, pero también defendiendo a la cavidad oral del ataque de patógenos externos que pueden causar, por ejemplo, la enfermedad periodontal. Esta revisión sistemática exploratoria, describe los mecanismos generales involucrados de la autofagia en diferentes patologías no neoplásicas que afectan al sistema estomatognático.

Autophagy is a process of lysosomal degradation and cell protection, which is intended to eliminate damaged organelles, misfolded proteins, and intracellular pathogens, making it an important process for human health. Autophagy acts as a modulator of pathogenesis and is a potential therapeutic target in various diseases, such as cancer, diabetes, or Parkinson's. In relation to the stomatognathic system, autophagy acts as aggravating or protecting oral diseases when it is increased, activated, or altered. The deregulation of autophagy mechanisms affects the development of autoimmunity through the survival of T lymphocytes and participates in the decrease and degeneration of glandular cells and basal keratinocytes in pathologies such as Sjögren's syndrome or oral lichen planus; It participates by modulating inflammation, but also by defending the oral cavity from the attack of external pathogens that can cause, for example, periodontal disease. This exploratory systematic review describes the general mechanisms involved in autophagy in different non-neoplastic pathologies that affect the stomatognathic system.

Apoyo social percibido en pacientes con Hipertensión Arterial y Diabetes Mellitus tipo II en Atención Primaria y su relación con autopercepción de salud / Social support, self-rated health, treatment adherence and effectiveness in patients with type II diabetes and hypertension

Background: A high level of social support (SS) is associated with better health outcomes in many conditions, such as chronic diseases. Aim : To describe the level of SS in patients with Hypertension and type II Diabetes at Primary Health Care level in Chile and its association with self-rated health, adherence to treatment and better glycemic and blood pressure control. Material and Methods : SS was measured using a social support inventory previously validated in Chile. Self-Rated Health was assessed with a single non-comparative general question; adherence to medication was assessed using the four-item Morisky medication adherence scale. Blood glucose and blood pressure control were also assessed. A logistic regression was performed to estimate Prevalence Odds Ratio (POR) and Robust Poisson method to estimate the Prevalence Ratio (PR). Results : Eighty three percent of the 647 participants evaluated high for SS. There was a significant correlation between SS and Self-rated health (POR 2.32; 95% confidence intervals (CI) 1.19-11.23; PR 1.18; 95% CI 1.07-1.31). No statistically significant association was observed with medication adherence, glycemic or blood pressure control. Conclusions: High levels of SS were found. The association between self-rated health suggests that SS interventions targeting vulnerable subgroups would be worthwhile.

The lived experience of undergraduate student parents: roles compatibility challenge.

OBJECTIVES: To reveal the meanings attributed by university students to their experience of becoming a mother/father during their studies. METHODS: A phenomenological study was conducted with students at a private Chilean University. Sixteen students from different undergraduate careers (eight women and eight men) participated in in-depth interviews, which were recorded. A phenomenological analysis of the data that followed the Streubert method was carried out, ensuring rigor by the criteria established by Guba and Lincoln during the research process. The ethical aspects were addressed through the process of informed consent, confidentiality and methodological rigor. RESULTS: The phenomenon of becoming a mother/father during the university studies was revealed through four central themes: Emotions in conflict; Internal mobilization to address the situation; Position oneself in a new role; and Need for support. The central contribution of the study is the revelation of the transformation process towards the integrated role of father/mother-student. CONCLUSIONS: This study provides qualitative evidence that contributes to a comprehensive understanding of the experience of becoming a mother/father during the university studies; concluding that this life experience is presented as a process of role compatibility, which is necessary to support. For this, it is necessary to make visible the role of parents/students in university policies, with the aim of providing concrete support during this process of parallel transition in the lives of young people.

La experiencia de estudiantes universitarios que son madres/padres: desafíos en la compatibilidad de roles / A experiência vivida por estudantes universitários que são mães/pais: desafios na compatibilidade dos papéis / The lived experience of undergraduate student parents: roles compatibility challenge

Objective. To reveal the meanings attributed by university students to their experience of becoming a mother/father during their studies. Methods. A phenomenological study was conducted with students at a private Chilean University. Sixteen students from different undergraduate careers (eight women and eight men) participated in in-depth interviews, which were recorded. A phenomenological analysis of the data that followed the Streubert method was carried out, ensuring rigor by the criteria established by Guba and Lincoln during the research process. The ethical aspects were addressed through the process of informed consent, confidentiality and methodological rigor. Results. The phenomenon of becoming a mother/father during the university studies was revealed through four central themes: Emotions in conflict; Internal mobilization to address the situation; Position oneself in a new role; and Need for support. The central contribution of the study is the revelation of the transformation process towards the integrated role of father/mother-student. Conclusion. This study provides qualitative evidence that contributes to a comprehensive understanding of the experience of becoming a mother/father during the university studies; concluding that this life experience is presented as a process of role compatibility, which is necessary to support. For this, it is necessary to make visible the role of parents/students in university policies, with the aim of providing concrete support during this process of parallel transition in the lives of young people. (AU)

La experiencia de estudiantes universitarios que son madres/padres: desafíos en la compatibilidad de roles Objetivo. Develar los significados atribuidos por estudiantes universitarios a su experiencia de convertirse en madre/padre durante sus estudios. Métodos. Se realizó un estudio fenomenológico en una universidad privada chilena. Dieciséis estudiantes de diferentes carreras de pregrado (ocho mujeres y ocho hombres) participaron en entrevistas en profundidad las cuales se grabaron. Se realizó un análisis fenomenológico de los datos que siguió el método de Streubert, cuidando el rigor de la investigación mediante el cumplimiento de los criterios establecidos por Guba y Lincoln durante el proceso de investigación. Resultados. El fenómeno de convertirse en madre/padre durante la etapa universitaria se develó a través de cuatro temas centrales: Emociones en conflicto; Movilización interna para abordar la situación; Posicionarse en un nuevo rol; y Necesidad de apoyo. La contribución central del estudio es la revelación del proceso de transformación hacia el rol integrado de padre/madre-alumno. Conclusión. Este estudio proporciona evidencia cualitativa que contribuye a una comprensión integral de la experiencia de convertirse en madre/padre durante la etapa universitaria. Como conclusión, esta experiencia de vida se presenta como un proceso de compatibilidad de roles, que es necesario apoyar. Para ello se requiere visibilizar el papel de los padres/madres estudiantes en las políticas universitarias con el objetivo de proporcionar un apoyo concreto durante este proceso de transición paralelo en la vida de los jóvenes.(AU)

A experiência vivida por estudantes universitários que são mães/pais: desafios na compatibilidade dos papéis Objetivo. Revelar os significados atribuídos por estudantes universitários à sua experiência de tornar-se em mãe/pai durante seus estudos. Métodos. Se realizou um estudo fenomenológico com estudantes numa Universidade particular chilena. Dezesseis estudantes de diferentes cursos de graduação (oito mulheres e oito homens) participaram em entrevistas em profundidade as quais foram gravadas. Se realizou uma análise fenomenológico dos dados que seguiu o método de Streubert, cautelando o rigor da investigação por meio do cumprimento dos critérios estabelecidos por Guba e Lincoln durante o processo de investigação. Resultados. O fenômeno de tornar-se em mãe/pai durante a etapa universitária se revelou através de quatro assuntos centrais: Emoções em conflito; Mobilização interna para abordar a situação; Posicionar-se num novo papel; e Necessidade de apoio. A contribuição central do estudo é a revelação do processo de transformação para o papel integrado de pai/mãe-aluno. Conclusão. Este estudo proporciona evidência qualitativa que contribui a uma compreensão integral da experiência de tornar-se em mãe/pai durante a etapa universitária; concluindo que esta experiência de vida se apresenta como um processo de compatibilidade de papéis, que é necessário apoiar. Para isto se requere visibilizar o papel dos pais/mães alunos nas políticas universitárias, com o objetivo de proporcionar um apoio concreto durante este processo de transição paralelo na vida dos jovens. (AU)

[Social support, self-rated health, treatment adherence and effectiveness in patients with type II diabetes and hypertension]. / Apoyo social percibido en pacientes con Hipertensión Arterial y Diabetes Mellitus tipo II en Atención Primaria y su relación con autopercepción de salud.

BACKGROUND: A high level of social support (SS) is associated with better health outcomes in many conditions, such as chronic diseases. AIM: To describe the level of SS in patients with Hypertension and type II Diabetes at Primary Health Care level in Chile and its association with self-rated health, adherence to treatment and better glycemic and blood pressure control. MATERIAL AND METHODS: SS was measured using a social support inventory previously validated in Chile. Self-Rated Health was assessed with a single non-comparative general question; adherence to medication was assessed using the four-item Morisky medication adherence scale. Blood glucose and blood pressure control were also assessed. A logistic regression was performed to estimate Prevalence Odds Ratio (POR) and Robust Poisson method to estimate the Prevalence Ratio (PR). RESULTS: Eighty three percent of the 647 participants evaluated high for SS. There was a significant correlation between SS and Self-rated health (POR 2.32; 95% confidence intervals (CI) 1.19-11.23; PR 1.18; 95% CI 1.07-1.31). No statistically significant association was observed with medication adherence, glycemic or blood pressure control. CONCLUSIONS: High levels of SS were found. The association between self-rated health suggests that SS interventions targeting vulnerable subgroups would be worthwhile.

[Psychometric properties of a spanish version of the Beck depression inventory IA]. / Propiedades psicométricas del inventario de depresión de Beck IA para la población chilena.

BACKGROUND: According to the Chilean National Health Survey (2009-2010), 17% of people aged 15 years or more have depressive symptoms. Thus, freely-available, easily-administered, and highly sensitive screening tests for depression are needed in clinical and research settings. AIM: To evaluate the psychometric properties of a Spanish version of the Beck Depression Inventory (BDI-IA) in adult Chilean population. MATERIAL AND METHODS: The inventory was applied to a sample of 1.105 adults aged between 18 to 73 years (94% women). Ninety nine participants were outpatients receiving treatment for affective disorders, 932 were parents and/or guardians of students enrolled in schools and 73 were university students (sample with no known depressive disorder). To perform data analysis, two groups from the random combination of both samples were generated. RESULTS: The inventory showed an appropriate degree of internal consistency (Cronbach alpha = .92). An exploratory factor analysis suggested a one-factor solution. This solution was reinforced with a confirmatory factor analysis, which displayed an adequate goodness of fit. The cutoff score, based on the Youden Index, was 13/14 points. It was able to discriminate between depressed and non-depressed participants. CONCLUSIONS: These results indicate that the BDI-IA is an appropriate instrument to assess depressive symptoms in Chilean adults.

Propiedades psicométricas del inventario de depresión de Beck IA para la población chilena / Psychometric properties of a spanish version of the Beck depression inventory IA

Background: According to the Chilean National Health Survey (2009-2010), 17% of people aged 15 years or more have depressive symptoms. Thus, freely-available, easily-administered, and highly sensitive screening tests for depression are needed in clinical and research settings. Aim: To evaluate the psychometric properties of a Spanish version of the Beck Depression Inventory (BDI-IA) in adult Chilean population. Material and Methods: The inventory was applied to a sample of 1.105 adults aged between 18 to 73 years (94% women). Ninety nine participants were outpatients receiving treatment for affective disorders, 932 were parents and/or guardians of students enrolled in schools and 73 were university students (sample with no known depressive disorder). To perform data analysis, two groups from the random combination of both samples were generated. Results: The inventory showed an appropriate degree of internal consistency (Cronbach alpha = .92). An exploratory factor analysis suggested a one-factor solution. This solution was reinforced with a confirmatory factor analysis, which displayed an adequate goodness of fit. The cutoff score, based on the Youden Index, was 13/14 points. It was able to discriminate between depressed and non-depressed participants. Conclusions: These results indicate that the BDI-IA is an appropriate instrument to assess depressive symptoms in Chilean adults.

Estilos de personalidad dependiente y autocrítico: desempeño cognitivo y sintomatología depresiva / Dependent and self-critical personality styles: Cognitive performance and depressive symptomatology

Resumen El presente estudio explora la relación entre las dimensiones de personalidad dependiente y autocrítica, con los déficits emocionales, cognitivos y sociales asociados a la sintomatología depresiva. La muestra del estudio la conformaron 91 estudiantes universitarios pertenecientes a la Pontificia Universidad Católica de Chile y a la Universidad de Chile, con edades comprendidas entre los 18 y 24 años. Para explorar el estado emocional de los participantes se utilizaron los test Inventario de Depresión de Beck (BDI) y Depressive Experiences Question naire (DEQ). Con el fin de evaluar el desempeño cognitivo, se utilizaron: una tarea tipo Stroop y la prueba de Tiempo de Reacción Serial (SSRT), y para evaluar el nivel de mentalización, la tarea de reconocimiento facial Reading the Mind in the Eyes Task (RMET) de Baron-Cohen. Se encontraron correlaciones significativas entre las dimensiones dependencia y autocrítica, la sintomatología depresiva y el desempeño cognitivo de los participantes.

Abstract This study examines the relationship between the dependent and self-criticism Cognitive dimensions of personality with emotional, cognitive and social deficits associated with depres-sive symptoms. The sample included 91 college students, aged 18 to 24, from Pontificia Universidad Católica de Chile and Universidad de Chile. The Beck Depression Inventory (BDI) and the Depressive Experiences Questionnaire (DEQ) tests were used in order to explore the emotional state of the participants. A Stroop task and a Serial Reaction Time (SSRT) test were used in order to assess cognitive performance. In turn, the Reading the Mind in the Eyes Task (RMET) face recognition task, by Baron-Cohen, was used to assess the mentalising capacity. Sig nificant correlations were found between dependency and self-criticism dimensions, depressive symptoms and cognitive performance of the participant.

Role of Personality Functioning in the Quality of Life of Patients with Depression.

Depression is associated with reduced quality of life (QoL), and personality pathology is associated with higher impairment and poorer treatment outcomes in patients with depression. This study aims to analyze the effects of personality functioning on the QoL of patients with depression. Severity of depressive symptoms (Beck Depression Inventory), level of personality functioning (Operationalized Psychodynamic Diagnosis Structure Questionnaire), and QoL (Medical Outcome Study 36-item Short-Form) were assessed in a sample of 84 depressive outpatients. Personality functioning showed main effects on both the mental and physical components of QoL. A moderating effect of personality functioning on the relationship between depressive symptoms and QoL was tested but not confirmed. Severity of depressive symptoms was found to mediate the effect of personality functioning on the mental component of QoL. These results suggest that the effect of personality functioning on the QoL of patients with depression may be related to the higher severity of depressive symptoms found in patients with lower levels of personality functioning.

Beyond Self-Criticism and Dependency: Structural Functioning of Depressive Patients and Its Treatment.

Van Praag states that the underlying psychic dysfunctions in psychopathology must be evaluated (and treated) in patient-centered treatments. In line with this idea, Blatt and colleagues propose the concept of self-critical (introjective) and dependent (anaclitic) functioning. The research program Millennium Initiative has studied self-critical and dependent functioning from different perspectives. The general aim of this paper is to share the results of the program that have contributed to clinical psychotherapeutic thinking. Its first specific aim is to summarize results reported elsewhere that support the predictive value of introjective and anaclitic functioning (Part I), while its second specific aim is to report original data that account for the structural functioning of personality underlying these two constructs (Part II). The results (Part I) show that self-critical functioning is associated with greater reactivity to stress (according to cortisol level in stress tasks) and less subjective awareness of stress, reduced performance in general tasks, and lower mentalization (errors in reading faces); also, patients with introjective (self-critical) depression receiving psychotherapy have more symptoms at onset, higher dropout rates, and poorer response to interventions than anaclitic (dependent) patients. Higher self-criticism was associated with higher depression scores; also, when comparing clinical and nonclinical samples, the latter showed less self-criticism. Therefore, self-critical functioning represents a challenge for researchers and clinicians. The evaluation of the structural functioning of personality showed (Part II) that self-critical functioning is associated with less integrated levels of structure and more depressive symptoms. This functioning is underlain by vulnerabilities in the abilities regulating object relationships and attachments to internal objects. Dependent functioning is associated with vulnerabilities in self-perception, self-regulation, and attachments to external objects. The psychotherapeutic implications of these results are discussed, paying special attention to aspects connected with structure-oriented psychotherapy.

Aspectos éticos del consentimiento informado: tópico fundamental en la investigación a lo largo de la historia / Ethical aspects of informed consent: fundamental topic of research throughout history

Las vulneraciones de los derechos humanos a lo largo de la historia desarrollaron las directrices éticas de la investigación científica. OBJETIVO: Reflexionar sobre los aspectos y principios éticos involucrados, características y principales conflictos actuales relacionados con el proceso del consentimiento informado (CI). RESULTADOS: Los resultados principales dejaron a la luz los principales conflictos al llevar a cabo investigaciones con poblaciones vulnerables, así como también las barreras asociadas a la aplicación y comprensión del proceso de CI. CONCLUSIÓN: La violación de derechos en seres humanos para la investigación dio pie a la creación del CI como medida ética y legal a quienes participan en ella, cuidando especialmente a poblaciones más vulnerables. Además la incorporación de esta temática a la formación de profesionales permitió defender los derechos de los participantes e impedir que actos crueles vuelvan a ocurrir.

Violations of human rights throughout history developed ethical guidelines for scientific research. AIM: Reflection on the aspects and ethical principles involved, main characteristics and current conflicts related to the process of informed consent (IC). RESULTS: The main results showwhat were the main conflicts in conducting research with vulnerable populations, as well as the barriers associated with the application and understanding of IC process. CONCLUSION: violation of human rights for research gaverise to the creation of CI as an ethical and legal measure to those involved in it, especially caring for vulnerable populations. In addition, the incorporation of this subject to the training of professionals allowed to defend the rights of the participants and to prevent cruel acts from happening again

[Mental health financing in Chile: a pending debt]. / Financiamiento de la salud mental en Chile: una deuda pendiente.

In spite of the high prevalence of mental health disorders in Chile, there is a significant financing deficit in this area when compared to the world's average. The financing for mental health has not increased in accordance with the objectives proposed in the 2000 Chilean National Mental Health and Psychiatry Plan, and only three of the six mental health priorities proposed by this plan have secure financial coverage. The National Health Strategy for the Fulfilment of Health Objectives for the decade 2011-2020 acknowledges that mental disorders worsen the quality of life, increase the risk of physical illness, and have a substantial economic cost for the country. Thus, this article focuses on the importance of investing in mental health, the cost of not doing so, and the need for local mental health research. The article discusses how the United States is trying to eliminate the financial discrimination suffered by patients with mental health disorders, and concludes with public policy recommendations for Chile.